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mtDNA单倍群X: 欧洲/西亚居民与北美土著间的基因联系

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发表于 2009-10-27 20:23 | 显示全部楼层 |阅读模式
mtDNA Haplogroup X: An Ancient Link between Europe/Western Asia and North America?

On the basis of comprehensive RFLP analysis, it has been inferred that ª97% of Native American mtDNAs belong to one of four major founding mtDNA lineages, designated haplogroups “A”–“D.” It has been proposed that a fifth mtDNA haplogroup (haplogroup X) represents a minor founding lineage in Native Americans. Unlike haplogroups A–D, haplogroup X is also found at low frequencies in modern European populations. To investigate the origins, diversity, and continental relationships of this haplogroup, we performed mtDNA high-resolution RFLP and complete control region (CR) sequence analysis on 22 putative Native American haplogroup X and 14 putative European haplogroup X mtDNAs. The results identified a consensus haplogroup X motif that characterizes our European and Native American samples. Among Native Americans, haplogroup X appears to be essentially restricted to northern Amerindian groups, including the Ojibwa, the Nuu-Chah-Nulth, the Sioux, and the Yakima, although we also observed this haplogroup in the Na-Dene–speaking Navajo. Median network analysis indicated that European and Native American haplogroup X mtDNAs, although distinct, nevertheless are distantly related to each other. Time estimates for the arrival of X in North America are 12,000–36,000 years ago, depending on the number of assumed founders, thus supporting the conclusion that the peoples harboring haplogroup X were among the original founders of Native American populations. To date, haplogroup X has not been unambiguously identified in Asia, raising the possibility that some Native American founders were of Caucasian ancestry.

发表:http://www.cell.com/AJHG/abstract/S0002-9297(07)61629-2
阅读:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377656
阅读:http://www.abdn.ac.uk/~gen155/lectures/brownwallace.pdf
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