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Recombination gives a new insight in the effective population size

发表于 2011-9-8 09:56 | 显示全部楼层 |阅读模式
本帖最后由 ranhaer 于 2012-3-21 20:08 编辑

Recombination gives a new insight in the effective population size and the history of the Old World human populations
Marta Melé1,  Asif Javed2,  Marc Pybus1,  Pierre Zalloua3,  Marc Haber3,  David Comas1,  Mihai G. Netea4,  Oleg Balanovsky5,6,  Elena Balanovska5,  Li Jin7,  Yajun Yang7,  RM. Pitchappan8,9,  G. Arunkumar9,  Laxmi Parida2,  Francesc Calafell1,  Jaume Bertranpetit1 and  The Genographic Consortium
Received April 4, 2011.
Revision received August 11, 2011.
Accepted August 12, 2011.

The information left by recombination in our genomes can be used to make inferences on our recent evolutionary history. Specifically, the number of past recombination events in a population sample is a function of its effective population size (Ne). We have applied a method, IRiS, to detect specific past recombination events in 30 Old World populations to infer their Ne. We have found that Sub-Saharan African populations have an Ne that is ~ 4 times greater than those of non-African populations and that outside of Africa, South Asian populations had the largest Ne. We also observe that the patterns of recombinational diversity of these populations correlate with distance out of Africa if that distance is measured along a path crossing South Arabia. No such correlation is found through a Sinai route, suggesting that anatomically modern humans first left Africa through the Bab-el-Mandeb strait rather than through present Egypt.

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