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PNAS: 另外两例丹人的线粒体

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发表于 2015-11-21 16:45 | 显示全部楼层 |阅读模式
本帖最后由 Ryan 于 2015-11-21 16:50 编辑

> Early Edition > Susanna Sawyer, doi: 10.1073/pnas.1519905112


Nuclear and mitochondrial DNA sequences from two Denisovan individuals

Susanna Sawyera,1, Gabriel Renauda,1, Bence Violab,c,d, Jean-Jacques Hublinc, Marie-Theres Gansaugea, Michael V. Shunkovd,e, Anatoly P. Dereviankod,f, Kay Prüfera, Janet Kelsoa, and Svante Pääboa,2

Abstract                           
Denisovans, a sister group of Neandertals, have been described on the basis of a nuclear genome sequence from a finger phalanx  (Denisova 3) found in Denisova Cave in the Altai Mountains. The only other Denisovan specimen described to date is a molar (Denisova 4) found at the same site. This tooth carries a mtDNA sequence similar to that of Denisova 3. Here we present nuclear DNA sequences from Denisova 4 and a morphological description, as well as mitochondrial and nuclear DNA sequence data, from another molar (Denisova 8) found in Denisova Cave in 2010. This new molar is similar to Denisova 4 in being very large and lacking traits typical of Neandertals and modern humans. Nuclear DNA sequences from the two molars form a clade with Denisova 3. The mtDNA of Denisova 8 is more diverged and has accumulated fewer substitutions than the mtDNAs of the other two specimens, suggesting Denisovans were present in the region over an extended period. The nuclear DNA sequence diversity among the three Denisovans is comparable to that among six Neandertals, but lower than that among present-day humans.                           
                        
Significance
Denisovans are a sister group of Neandertals that were identified on the basis of a nuclear genome sequence from a bone from Denisova Cave (Siberia). The only other Denisovan specimen described to date is a molar from the same site. We present here  nuclear DNA sequences from this molar and a morphological description, as well as mitochondrial and nuclear DNA sequences from another molar from Denisova Cave, thus extending the number of Denisovan individuals known to three. The nuclear DNA sequence diversity among the Denisovans is higher than among Neandertals, but lower than among present-day humans. The mtDNA of one molar has accumulated fewer substitutions than the mtDNAs of the other two specimens, suggesting Denisovans were present in the region over several millennia.                           
                        

发表及全文:
http://intl.pnas.org/content/early/2015/11/11/1519905112.abstract

Sawyer et al. 2015, mtDNA of two Denisovan individuals.pdf

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发表于 2015-11-21 16:51 | 显示全部楼层
核dna多态性高于尼人,mtdna反而更低?这是怎么回事?
 楼主| 发表于 2015-11-21 16:55 | 显示全部楼层
Sawyer et al. 2015, Fig. 2.

其中一例的线粒体积累的突变比其他两例少很多,说明丹人已经在这一区域生活了很长的时间。

能发现这个洞穴实在是幸运。相信不久之后就能看到另外两个丹人的基因组数据。
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