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蓝海人类学在线 Ryan WEI's Forum of Anthropology

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遼寧漢族639例mtDNA

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发表于 2017-8-29 12:03 | 显示全部楼层 |阅读模式
Association between mitochondrial DNA variations and schizophrenia in the northern Chinese Han population

Abstract

To determine whether mitochondrial DNA (mtDNA) variations are associated with schizophrenia, 313 patients with schizophrenia and 326 unaffected participants of the northern Chinese Han population were included in a prospective study. Single-nucleotide polymorphisms (SNPs) including C5178A, A10398G, G13708A, and C13928G were analyzed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Hypervariable regions I and II (HVSI and HVSII) were analyzed by sequencing. The results showed that the 4 SNPs and 11 haplotypes, composed of the 4 SNPs, did not differ significantly between patient and control groups. No significant association between haplogroups and the risk of schizophrenia was ascertained after Bonferroni correction. Drawing a conclusion, there was no evidence of an association between mtDNA (the 4 SNPs and the control region) and schizophrenia in the northern Chinese Han population.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182769
发表于 2017-11-2 14:11 | 显示全部楼层
这个有具体mtdna的类型比例么?
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