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新石器时代姜家梁和三关人群的遗传多样性为农业在中国北方的扩张提供了证据

Genetic diversity of two Neolithic populations provides evidence of farming expansions in North China

Ye Zhang, Jiawei Li, Yongbin Zhao, Xiyan Wu, Hongjie Li, Lu Yao, Hong Zhu and Hui Zhou
Journal of Human Genetics , 1 September 2016

Abstract:The West Liao River Valley and the Yellow River Valley are recognized Neolithic farming centers in North China. The population dynamics between these two centers have significantly contributed to the present-day genetic patterns and the agricultural advances of North China. To understand the Neolithic farming expansions between the West Liao River Valley and the Yellow River Valley, we analyzed mitochondrial DNA (mtDNA) and the Y chromosome of 48 individuals from two archeological sites, Jiangjialiang (>3000 BC) and Sanguan (~1500 BC). These two sites are situated between the two farming centers and experienced a subsistence shift from hunting to farming. We did not find a significant difference in the mtDNA, but their genetic variations in the Y chromosome were different. Individuals from the Jiangjialiang belonged to two Y haplogroups, N1 (not N1a or N1c) and N1c. The individuals from the Sanguan are Y haplogroup O3. Two stages of migration are supported. Populations from the West Liao River Valley spread south at about 3000 BC, and a second northward expansion from the Yellow River Valley occurred later (3000–1500 BC).


http://www.nature.com/jhg/journal/vaop/ncurrent/full/jhg2016107a.html
古DNA强文!看来河北是新石器时代O和N的拉锯战的区域。希望早日看到全文。
NRY: O2a1c1a1a1a1a1a1a1a1(源自粤西云浮)
mtDNA:B4d1(源自浙北慈溪)
百越人的人类学文集 http://blog.sina.com.cn/baiyueren
还没有看到全文,见了别人抄在网上的一段:
    The resulting Y-chromosome analysis indicated the presence of a rare haplogroup N1c-Tat in the JJL population. This is an unexpecte result for ancient populations in North China. Searching through previously reported Y-chromosome variations for 119 known ancient individuals from 13 archeological sites (approximately dated to 6000-2000 years ago) in North China, the N1c-Tat was found in only three individuals from the Bronze Age Dashanqian site (~1000 BC) in the West Liao River Valley.[38,39,45]
    Considering the rarity of the N1c-Tat haplogroup distribution in the ancient populations throughout the late Neolithic and Bronze Ages, it is possible that N1c-Tat represented the local population of the Sanggan River Valley. These people may be the original settlers who used a hunter-gatherer subsistence strategy in the Sanggan River Valley. During the shift from hunting to farming, they likely embraced new techniques and then began to use farming technology.
    The haplogroup N1 (×N1a, ×N1c) was widely distributed at a high density in ancient populations of North China but at a much lower frequency in modern East Asian populations.[42] Previous studies supported that haplogroup N1 expanded into North China 12–18 kya.[46,47] High-frequency distributions of N1 (×N1a ,×N1c) (Table 2) were observed in populations from the West Liao River Valley during the Neolithic and early Bronze Age,[38] showing that it became the dominant Y-chromosome lineage of North China at that time. Through the West Liao River Valley, researchers argued that the N1 (×N1a, ×N1c) haplogroup migrated to northwestern China (for example, the Bronze Age Tianshanbeilu site in Xinjiang)[43] and the Yellow River Valley (for example, the Hengbei site).[48]
    The presence of N1 (×N1a, ×N1c) haplogroup in the ancient JJL population suggested that this population maybe in close affinity with the West Liao River Valley populations. This suggests possible genetic exchanges between the West Liao River Valley and the Sanggan River Valley populations.
    Haplogroup O3-M122 is the main lineage of the Yellow River Valley.[49] It is, however, not present in the JJL population by this study. Artifacts excavated from the JJL site also showed more stylistic features of the Hongshan culture of the West Liao River Valley.[19]
    Genetic and archeological evidence indicates that people from the Yellow River Valley probably did not reach the Sanggan River Valley before 3000 BC. Therefore, people from the West Liao River Valley, not the Yellow River Valley, most likely first influenced the agricultural practices in the Sanggan River Valley.
mt
mt.png
2016-9-5 13:05


y
y.png
2016-9-5 13:05
姜家梁有和红山文化类似的玉猪龙造型。这次是从YDNA的角度证明了姜家梁属于辽河南下河北的人群。
NRY: O2a1c1a1a1a1a1a1a1a1(源自粤西云浮)
mtDNA:B4d1(源自浙北慈溪)
百越人的人类学文集 http://blog.sina.com.cn/baiyueren
4# 198401 N的y-str提取成功,O的失败??
没意思
str.png
2016-9-5 13:23
新成果啊,
从mtDNA看,蔚县三关的确比姜家梁南很多。

姜家梁蔚县三关.jpg
2016-9-5 14:26
NRY: O2a1c1a1a1a1a1a1a1a1(源自粤西云浮)
mtDNA:B4d1(源自浙北慈溪)
百越人的人类学文集 http://blog.sina.com.cn/baiyueren
这个机构有意思    专门测那些边缘地带的遗址

这个张家口的姜家梁  地处晋语区  靠近内蒙    海拔1400米   之前测的蔚县三关也是张家口的 海拔900多米

不是说边缘地带的没有意义

他们既然手上也有中原地区的遗骨  为什么不测一测呢  忌讳什么
海岛小世界
10# Hanhe
姜家梁测年是>5kya,跟传说中的华夏五千年文明并不冲突。
现在唯一不确定的是,龙的原型是否是来自红山和姜家梁的玉猪龙。
NRY: O2a1c1a1a1a1a1a1a1a1(源自粤西云浮)
mtDNA:B4d1(源自浙北慈溪)
百越人的人类学文集 http://blog.sina.com.cn/baiyueren
三关的o3是不能提取吗?还是就是o3的祖型p201而已?

不过这种猜测,我是有小两年了,好像越来越可以证明接近真的,大汶口的p201应该就是夏后氏,如果上古传说为确的话,应该也是所谓的黄帝族系。1500bc的母系跟3000bc的母系类似,因为本就是从N1 m117系人在2600bc炎黄大战中抢来的"炎帝女娃“
刚看到文献全文和附件,4例O3的17 Y-str全部null,而且不知道是真没测下游,还是更以往一样,一贯传统,下游阴性结果就不提了,还是真只想测了个M122就了事了。
新技术方案尝试:低覆盖全基因组,最低成本深度解析父系源流,略有成效,大家一起摸索。微博@基因人王冰 QQ群:387100816。
本帖最后由 Yungsiyebu 于 2017-7-10 15:30 编辑

吉大的数据质量没有y-str的真不能轻易相信。

JJL37 snp定性为N1c,y-str匹配是非常把握的C3。

No.Populationlocation,freSNP
2106Hanzhejiang1
687KoreanKorean1
Ht73XibeLiaoning1
H865HanHenan1
H638HanShandong1
BR576BuryatSiberia1
ID0657Hanhenan1
ID0658Hanhenan1
4KazakhShymkent1M217(xM48)
34KazakhArys1M217(xM48)
38KazakhArys1M217(xM48)
107KazakhArys1M217(xM48)
JJL371N1c


19385a385b389AB389CD390391392
1512191315231011
1612191415231011
1612191415231011
1712201415231011
1612191515231011
1512191315231011
1512191415231011
1512191415231011
1612201315231011
1512201415231011
1612191415231011
1612201415231011
null122414152310null


393437438439448456458635H4
141410142115182110
141410122115172111
141410132115182111
141410132115182110
141410122116172111
141410122115182211
141410132015182011
141410132015182011
141410132115182111
141410122115182111
141410122116172111
141410122116172111
141410122116172111
新技术方案尝试:低覆盖全基因组,最低成本深度解析父系源流,略有成效,大家一起摸索。微博@基因人王冰 QQ群:387100816。
本帖最后由 Yungsiyebu 于 2017-7-10 15:13 编辑

顺序:

原报告snp分型 编号 Y-str匹配分型。

N1*的str都是吻合的,应当没有问题。

N1c多个样本有问题,有的N南支,有1个是C3,但的确有N1c。

N1(×N1a,N1c)JJL3M231N-south
N1(×N1a,N1c)JJL6M231N-south
N1(×N1a,N1c)JJL25M231N-south
N1(×N1a,N1c)JJL40M231N-south
N1(×N1a,N1c)JJL63zM231N-south
N1(×N1a,N1c)JJL9M231N-south
N1(×N1a,N1c)JJL10M231N-south
N1(×N1a,N1c)JJL11M231N-south
N1(×N1a,N1c)JJL16M231N-south
N1(×N1a,N1c)JJL29M231N-south
N1cJJL36M231N-south
N1cJJL37M217C3
N1cJJL57M231N-south
N1cJJL69TatN-North
N1cJJL20dTatN-North
N1cJJL13M231N-south
N1cJJL27M231N-south
O3SG1
O3SG2
O3SG3
O3SG4

y-str jiangjialiang.xlsx (12.93 KB)

新技术方案尝试:低覆盖全基因组,最低成本深度解析父系源流,略有成效,大家一起摸索。微博@基因人王冰 QQ群:387100816。
本帖最后由 拓扑维度 于 2017-7-1 22:54 编辑


此图出自中国农业部:从周商时期至汉代,黄河下游地区土地肥沃冠天下, 主要粮食作物产区几乎都在山东及其周围地区,而西北地区、北方地区都是游牧民族的主要养马地区,对于东方农业文明构成严重的威胁。
吉大的数据质量没有y-str的真不能轻易相信。

JJL37 snp定性为N1c,y-str匹配是非常把握的C3。


        No.  Population  location,  fre  SNP    2106  Han  zhejiang  1      687  Korean  Korean  1       ...
Yungsiyebu 发表于 2017-7-1 19:56
吉大的数据其实不止SNP,y-str也是有很大问题的,比较典型的问题是DYS385a/b基因座,牛河梁测到的那例C的DYS385a/b的值是14.2,忽略该值剩余数据很接近C2南支。井沟子数据的DYS385a/b是14-17左右,忽略该值剩余数据是典型的C2-F3918。而这份姜家梁数据中的JJL37的DYS385a/b的值是12/24,忽略该值剩余数据匹配到最近的也都是C2南支。
最大的问题在于吉大测到的这些DYS385ab的组合在现代C2单倍群样本中从没见到过,如果不是测试的错误很难解释的过去。同样,其他基因座也难免同样的问题。
C-M130交流群:542136235
毕竟str基因座多,忽略疑似问题位点,还是可以基本分型的,如果井沟子组更似F3918,那么,东胡的问题就逐渐清晰了。我也准备重新把吉大的str重新做下分型推测,snp不可靠。
新技术方案尝试:低覆盖全基因组,最低成本深度解析父系源流,略有成效,大家一起摸索。微博@基因人王冰 QQ群:387100816。
古DNA的str其实是最不可信的,所以你们再以后要以snp分型为准
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