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Eye colour: portals into pigmentation genes and ancestry

Trends in Genetics  Volume 20, Issue 8 , 1 August 2004, Pages 327-332
Eye colour: portals into pigmentation genes and ancestry
Richard A. Sturm, and Tony N. Frudakis

Abstract
Several recent papers have tried to address the genetic determination of eye colour via microsatellite linkage, testing of pigmentation candidate gene polymorphisms and the genome wide analysis of SNP markers that are informative for ancestry. These studies show that the OCA2 gene on chromosome 15 is the major determinant of brown and/or blue eye colour but also indicate that other loci will be involved in the broad range of hues seen in this trait in Europeans.


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