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Evaluating self-declared ancestry of U.S. Americans with........

本帖最后由 198401 于 2011-1-2 16:56 编辑

    Evaluating self-declared ancestry of U.S. Americans with autosomal, Y-chromosomal and mitochondrial DNA
    Oscar Lao1,Peter M. Vallone2,Michael D. Coble3,Toni M. Diegoli3,Mannis van Oven1,Kristiaan J. van der Gaag4,Jeroen Pijpe4,Peter de Knijff4,Manfred Kayser1,
    Article first published online: 30 SEP 2010

DOI: 10.1002/humu.21366

Keywords:
  • U.S. Americans;genetic ancestry;self-declared ancestry;ASM;AIM;Y-chromosome;NRY;mtDNA


Abstract
The current U.S. population represents an amalgam of individuals originating mainly from four continental regions (Africa, Europe, Asia and America). To study the genetic ancestry and compare with self-declared ancestry we have analyzed paternally, maternally and bi-parentally inherited DNA markers sensitive for indicating continental genetic ancestry in all four major U.S. American groups. We found that self-declared U.S. Hispanics and U.S. African Americans tend to show variable degrees of continental genetic admixture among the three genetic systems, with evidence for a marked sex-biased admixture history. Moreover, for these two groups we observed significant regional variation across the country in genetic admixture. In contrast, self-declared U.S. European and U.S. Asian Americans were genetically more homogeneous at the continental ancestry level. Two autosomal ancestry-sensitive markers located in skin pigmentation candidate genes showed significant differences in self-declared U.S. African Americans or U.S. European Americans, relative to their assumed parental populations from Africa or Europe. This provides genetic support for the importance of skin color in the complex process of ancestry identification. © 2010 Wiley-Liss, Inc.




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