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四川汉族群体8个Y-STR的遗传分析

国际遗传学杂志 > 2009年6期

四川汉族群体8个Y-STR的遗传分析

作 者: 唐剑频    蒋丰慧    侯一平   
作者单位: 唐剑频,TANG Jian-pin(广东医学院法医学教研室,东莞,523808)
蒋丰慧,JIANG Feng-hui(广东医学院东莞校区门诊部,东莞,523808)
侯一平,HOU Yi-ping(四川大学华西基础医学与法医学院,成都,61004)  


摘要:目的 调查四川汉族群体8个Y染色体STR的遗传多态性,分析8个Y染色体STR的等位基因序列.方法 利用非变性聚丙烯酰胺凝胶电泳对8个Y-STR基因座进行分型.结果 DYS443、DYS453、DYS455、DYS456是简单重复序列的Y-STR,DYS444、DYS448、DYS457、DYS458是复杂重复序列的Y-STR.108位男性个体观察到106种单体型.8个Y-STR的基因变异度在0.355~0.821之间,单体型变异度为0.9996.结论 在四川汉族群体,8个基因座构成的单体型具有较好的个人识别能力和非父排除率.
Abstract:Objective To analyze the genetic polymorphism of 8 Y-STR loci in Han population of Sichuan, and the allelic sequences of 8 Y-STRs. Methods the PCR products of 8 Y-STR were genotyped using non-denatured polyacrylamide gel electrophoresis. Results DYS443, DYS453, DYS455, and DYS456 are Y-STRs with the simple repeat motif, and DYS444, DYS448, DYS457, and DYS458 are Y-STRs with the complex repeat motif. A total of 106 haplotypes were observed at 8-Y-STRs in 108 males. The gene diversities of 8 Y-STR ranged from 0. 355-0. 821, and the diversity of haplotype was 0. 9996. Conclusion The discrimination power and the probability of paternity exclusion at 8 Y-STR were higher in Sichuan Han population.

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