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尼安德特人mtDNA贡献分析

Estimating Neandertal contribution to the Upper Paleolithic H. sapiens gene pool using genetic drift effect in branching process model

KRZYSZTOF A. CYRAN etc.

Abstract:

In the paper, there is considered the effect of the genetic drift, which could eliminate the hypothetical Neandertal mtDNA admixture from the Upper Paleolithic gene pool of anatomically modern humans. To model the demography, the slightly supercritical Markov’s branching process (BP) based on the
O’Connell model has been proposed. Relying on relatively fast convergence to the O’Connell’s limiting properties it is possible to estimate the time of extinction of the Neandertals relatively to the time of the root of the mtDNA polymorphism of modern humans. The results of the study indicate that the maximum hypothetical contribution of Neandertal mtDNA which could be eliminated by the genetic drift at 0.05 significance level is about 12% for studying mtDNA record only. However, the expected value of the admixture, estimated to be about 3.9 % based on mtDNA record only, is reduced to around 2.3 % if additional nuclear genome data is utilized for Bayesian inference. Relevance of the paper lies in treating mtDNA-based studies as complementary
approaches to those based on nuclear DNA sequenced by the Neandertal genome project.
Key-Words: scientific computations, Bayesian inferring, mitochondrial DNA, branching process, genetic drift, Neandertals-H. sapiens interactions

http://www.wseas.us/e-library/conferences/2012/Paris/ECCS/ECCS-08.pdf
没注意到这篇文章,真的很有帮助的~
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
我对第一作者的姓氏很感兴趣,应该怎么念?是塞尔维亚人吗?
:-)
3# bugz
应该是波兰人。
KRZYSZTOF好像不是姓,是他的名字,any clue?
:-)
4# 198401

哦,谢
:-)
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