返回列表 回复 发帖

The complete genome sequence of a 45,000-year-old modern human from Eurasia

本帖最后由 Ryan 于 2014-6-6 14:06 编辑

SMBE 2014 Ancient Genomics

https://mcidublin.conference-ser ... 8&abstractID=811773

"We have sequenced to high coverage the genome of a femur recently discovered near Ust-Ishim in Siberia. The bone was directly carbon-dated to 45,000 years before present. Analyses of the relationship of the Ust-Ishim individual to present-day humans show that he is closely related to the ancestral population shared between present-day Europeans and present-day Asians. The over-all amount of genomic admixture from Neandertals is similar to that in present-day non-Africans and there is no evidence for admixture from Denisovans. However, the size of the genomic segments of Neandertal ancestry in the Ust-Ishim individual is substantially larger than in present-day individuals. From the size distribution of these segments we estimated that this individual lived about 200-400 generations after the admixture with Neandertals occurred. The age of this genome allows us to directly assess the mutation rate in the different compartments of the human genome. These results will be presented and discussed."
值得期待。
极品猥琐凤凰眼镜生物党棍左棍五毛愤青爱国
eight代 poor农 root正 shoot
大胆预测一下:此君Y会是F下今天没有的一支,MT会是U下今天没有的一支。跟MA-1一样,此君没有直系后代。
极品猥琐凤凰眼镜生物党棍左棍五毛愤青爱国
eight代 poor农 root正 shoot
网上可以搜到的信息比一楼的会议报告摘要里的多一些。但是文章还没有出,Y单倍型还没有公布。mtDNA单倍群类型据网上听过Fu Qiaomei一次有关讲演的人说是R。

我的三个印象。(1)测序的平均覆盖率是42倍。(2)按今天的人的数据,mtDNA单倍型M和N在距今50000-59000年前成为人群中的成分。因为R是N之下的分支,所以45000年前的R与此相符合。(3)按这人的DNA来估计,与尼人的混合发生在他的331加减99代以前,距今50000-60000年。按今天的人(French, Sardinian, Han, Dai, Karitiana)的数据,简单假定有过一次混合,估计出的时间区间比较宽,距今37000-86000年。

下面是几个链接。
Svante Paabo在美国国立卫生研究院(NIH)的一次有关讲演:
http://www.youtube.com/watch?v=M7VdRKQuAa8
如果接不通,也许下面的链接可用:
http://dienekes.blogspot.com/201 ... bo-talk-at-nih.html
http://aratta.wordpress.com/2014/04/14/svante-paabo-talk-at-nih
美国国立卫生研究院关于这次讲演的报导:
http://nihrecord.nih.gov/newsletters/2014/05_23_2014/story1.htm

有人在听Fu Qiaomei的一次有关讲演时做的一页笔记:
http://snag.gy/IzthP.jpg

Ust-Ishim, 按谷歌翻译是俄罗斯,鄂木斯克州,乌斯季 - 伊希姆区,不知准不准。
大体与石叶工业的传播吻合,找不到考古学依据的沿海迁徙理论,渐渐被古dna证据冲散。
新技术方案尝试:低覆盖全基因组,最低成本深度解析父系源流,略有成效,大家一起摸索。微博@好奇云怪 QQ群:387100816。
种种特点听起来很像basal Eurasian,与今天的欧亚人种相差均远。
O3a3c* (M134+, M117-)
6# hercules 未必是basal Eurasian,也有可能走向东亚的一个小分支。
Analyses of the relationship of the Ust-Ishim individual to present-day humans show that he is closely related to the ancestral population shared between present-day Europeans and present-day Asians.
Tocharian_2 发表于 2014-6-6 13:58
這段話的意思好像是說,該古人的遺傳組成,與今日歐洲人及亞洲人的共祖群體關係密切,不知道這共祖群體是不是指K-M526,包括K2a(NO)及K2b(M、S、P等支系)。

Improved phylogenetic resolution and rapid diversification of Y-chromosome haplogroup K-M526 in Southeast Asia:
http://www.ranhaer.com/thread-28528-1-1.html


Y染色體:O3 M134+ M117-
mtDNA:D5a2
是不是就是那个田园洞人的全序?这个会有Y吗?
是不是就是那个田园洞人的全序?这个会有Y吗?
ranger 发表于 2014-6-23 15:56
"We have sequenced to high coverage the genome of a femur recently discovered near Ust-Ishim in Siberia"
10# Tocharian_2 不好意思,没注意到,
8# natsuya 如果这具古尸是和Y-C1相关的话,也会是和现代欧洲和东亚人群密切相关,但显然不会是主流。
這段話的意思好像是說,該古人的遺傳組成,與今日歐洲人及亞洲人的共祖群體關係密切,不知道這共祖群體是不是指K-M526,包括K2a(NO)及K2b(M、S、P等支系)。

Improved phylogenetic resolution and rapid diversif ...
natsuya 发表于 2014-6-23 15:36
常染色体方面的,未必与Y贴合。我觉得与今天高加索地区和西亚一带人最接近
O3a3c* (M134+, M117-)
大体与石叶工业的传播吻合,找不到考古学依据的沿海迁徙理论,渐渐被古dna证据冲散。
Yungsiyebu 发表于 2014-6-23 14:15
O3a3c* (M134+, M117-)
大体与石叶工业的传播吻合,找不到考古学依据的沿海迁徙理论,渐渐被古dna证据冲散。
Yungsiyebu 发表于 2014-6-23 14:15
O3a3c* (M134+, M117-)
常染色体方面的,未必与Y贴合。我觉得与今天高加索地区和西亚一带人最接近
hercules 发表于 2014-6-23 17:37
的確,看摘要更可能是講常染色體的共祖,Y不見得吻合。比較耐人尋味的,他說歐洲人和亞洲人的共祖群體成分,但沒有提到中東人和非洲人,是不是說這個共祖群體的常染影響主要融入歐洲人和亞洲人。
Y染色體:O3 M134+ M117-
mtDNA:D5a2
8# natsuya 如果这具古尸是和Y-C1相关的话,也会是和现代欧洲和东亚人群密切相关,但显然不会是主流。
wolfgang 发表于 2014-6-23 16:32
Yes,摘要應該是講常染影響,Y可能不能完全對應。
Y染色體:O3 M134+ M117-
mtDNA:D5a2
的確,看摘要更可能是講常染色體的共祖,Y不見得吻合。比較耐人尋味的,他說歐洲人和亞洲人的共祖群體成分,但沒有提到中東人和非洲人,是不是說這個共祖群體的常染影響主要融入歐洲人和亞洲人。
natsuya 发表于 2014-6-23 18:09
只要是和亚洲对比,欧洲学者默认中东北非就是欧洲成分
的確,看摘要更可能是講常染色體的共祖,Y不見得吻合。比較耐人尋味的,他說歐洲人和亞洲人的共祖群體成分,但沒有提到中東人和非洲人,是不是說這個共祖群體的常染影響主要融入歐洲人和亞洲人。
natsuya 发表于 2014-6-23 18:09
这也未必吧,要注意这是四五万年前的古DNA,即使他所在人群没有发展成欧亚人,他仍有可能比现代的欧亚人更接近欧亚人的祖先。
Ust-Ishim.JPG
O3a3c* (M134+, M117-)
文章正式发表了。

Genome sequence of a 45,000-year-old modern human from western Siberia

Nature 514, 445-449 (23 October 2014)  doi:10.1038/nature13810
Received 15 May 2014 Accepted 29 August 2014 Published online 22 October 2014

Qiaomei Fu, Heng Li, Priya Moorjani, Flora Jay, Sergey M. Slepchenko, Aleksei A. Bondarev, Philip L. F. Johnson, Ayinuer Aximu-Petri, Kay Prüfer, Cesare de Filippo, Matthias Meyer, Nicolas Zwyns, Domingo C. Salazar-García, Yaroslav V. Kuzmin, Susan G. Keates, Pavel A. Kosintsev, Dmitry I. Razhev, Michael P. Richards, Nikolai V. Peristov, Michael Lachmann, Katerina Douka, Thomas F. G. Higham, Montgomery Slatkin, Jean-Jacques Hublin, David Reich, Janet Kelso, T. Bence Viola & Svante Pääbo

Abstract
We present the high-quality genome sequence of a ~45,000-year-old modern human male from Siberia. This individual derives from a population that lived before - or simultaneously with - the separation of the populations in western and eastern Eurasia and carries a similar amount of Neanderthal ancestry as present-day Eurasians. However, the genomic segments of Neanderthal ancestry are substantially longer than those observed in present-day individuals, indicating that Neanderthal gene flow into the ancestors of this individual occurred 7,000-13,000 years before he lived. We estimate an autosomal mutation rate of 0.4 × 10-9 to 0.6 × 10-9 per site per year, a Y chromosomal mutation rate of 0.7 × 10-9 to 0.9 × 10-9 per site per year based on the additional substitutions that have occurred in present-day non-Africans compared to this genome, and a mitochondrial mutation rate of 1.8 × 10-8 to 3.2 × 10-8 per site per year based on the age of the bone.


全文和附件:http://www.nature.com/nature/journal/v514/n7523/full/nature13810.html
http://www.nature.com/nature/journal/v514/n7523/extref/nature13810-s1.pdf
返回列表
baidu
互联网 www.ranhaer.org