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[2015]如皋长寿村线粒体研究

Mitochondrial genomes and exceptional longevity in a Chinese population: the Rugao longevity study.

Li L1, Zheng HX, Liu Z, Qin Z, Chen F, Qian D, Xu J, Jin L, Wang X.

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Abstract

Genetic variants of whole mitochondrial DNA (mtDNA) that predispose to exceptional longevity need to be systematically identified and appraised. Here, we conducted a case-control study with 237 exceptional longevity subjects (aged 95-107) and 444 control subjects (aged 40-69) randomly recruited from a "longevity town"-the city of Rugao in China-to investigate the effects of mtDNA variants on exceptional longevity. We sequenced the entire mtDNA genomes of the 681 subjects using a next-generation platform and employed a complete mtDNA phylogenetic analytical strategy. We identified T3394C as a candidate that counteracts longevity, and we observed a higher load of private nonsynonymous mutations in the COX1 gene predisposing to female longevity. Additionally, for the first time, we identified several variants and new subhaplogroups related to exceptional longevity. Our results provide new clues for genetic mechanisms of longevity and shed light on strategies for evaluating rare mitochondrial variants that underlie complex traits.


http://www.ncbi.nlm.nih.gov/pubmed/25666573
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Longevity.png
2015-2-28 23:35
查了下MT全序的文件6386C-->T这个点我有,但2833A-->G这个点没有。
这篇研究与之前这篇结论类似吧
Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity.
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