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Genomic analyses inform on migration events during the peopling of Eurasia

Luca Pagani,   Daniel John Lawson,   Evelyn Jagoda,   Alexander Mörseburg,   Anders Eriksson,   Mario Mitt,   Florian Clemente,   Georgi Hudjashov,   Michael DeGiorgio,   Lauri Saag,   Jeffrey D. Wall,   Alexia Cardona,   Reedik Mägi,   Melissa A. Wilson Sayres,   Sarah Kaewert,   Charlotte Inchley,   Christiana L. Scheib,   Mari Järve,   Monika Karmin,   Guy S. Jacobs,   Tiago Antao,   Florin Mircea Iliescu,   Alena Kushniarevich,   Qasim Ayub,   Chris Tyler-Smith   et al

High-coverage whole-genome sequence studies have so far focused on a limited number1
of geographically restricted populations2,
3,
4,
5, or been targeted at specific diseases, such as cancer6. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history7,
8,
9
and refuelled the debate on the mutation rate in humans10. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record11, and admixture between AMHs and Neanderthals predating the main Eurasian expansion12, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago.


http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19792.html
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  • 豢龙氏

三界无安,犹如火宅。众苦充满,甚可怖畏
                            --------《法华经》
是以法从心生。名因法立
                      ------------《宗镜录》
跟我以前推断一致,希望能看到全文。
O3a3c* (M134+, M117-)
http://cloud.189.cn/t/vQvqi23Ar6zu(访问码:6623)
看了原文,不错,篇幅不长,但是很精确地说明了xOOA在南线人群中的基因遗留。
文中提及湖南道县80kya古人牙齿,可惜至今没看到基因报告,希望中国人努力尽快补上
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
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